Raw mushrooms have a gastrointestinal irritant, hydrazine, but parboiling or blanching before consumption will remove it.
en.wikipedia.org The bark bears a gooey sap that was once used as a topical remedy for mucous membrane irritation and for gastrointestinal upset.
en.wikipedia.org It is employed as a purgative, for gastrointestinal and liver conditions, for hernias and urethral discharge or for sores and wounds.
en.wikipedia.org The anthranoid laxatives pass through the gastrointestinal tract unabsorbed until they reach the large intestine, where they are changed into their active forms.
en.wikipedia.org Workload has been linked to a number of strains, including anxiety, physiological reactions such as cortisol, fatigue, backache, headache, and gastrointestinal problems.
en.wikipedia.org