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Übersetzungen für „aminopterin“ im Englisch » Polnisch-Wörterbuch (Springe zu Polnisch » Englisch)
aminopterin SUBST
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Englisch
- That compound -- aminopterin -- was the predecessor of methotrexate, a cancer treatment drug that is still used commonly today.ottawacitizen.com
- These analogues first aminopterin and then amethopterin (now methotrexate) were antagonistic to folic acid, and blocked the function of folate-requiring enzymes.en.wikipedia.org
- Aminopterin is a synthetic derivative of pterin.en.wikipedia.org
- The use of aminopterin in cancer treatment was supplanted in the 1950s by methotrexate due to the latter's better therapeutic index in a rodent tumor model.en.wikipedia.org
- In contrast, animals given aminopterin in an amount of 0.041 mg/kg/day x 6 days without folic acid died.en.wikipedia.org
- After fusion, the cells are grown in a medium with methotrexate or aminopterin that inhibit the enzyme dihydrofolate reductase thus blocking the de novo synthesis of thymidine monophosphate.en.wikipedia.org
- Animal studies published in 1956 showed the therapeutic index of methotrexate was better than that of aminopterin, and clinical use of aminopterin was thus abandoned in favor of methotrexate.en.wikipedia.org
- Often the de novo pathway is interrupted as a result of chemotherapy drugs such as methotrexate or aminopterin.en.wikipedia.org
- Aminopterin blocks the pathway that allows for nucleotide synthesis.en.wikipedia.org
- Aminopterin in the medium blocks the de novo pathway.en.wikipedia.org
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