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carboxyl group CHEM

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Englisch
In proteins, the secondary structure is defined by the patterns of hydrogen bonds between backbone amino and carboxyl groups.
en.wikipedia.org
It is an isomer of nicotinic acid, which has the carboxyl side chain at the 3-position.
en.wikipedia.org
Release of the carboxyl carbon (via ninhydrin) from amino acids recovered from soil that has been treated with a labeled substrate demonstrates assimilation of that substrate into microbial protein.
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This led to the conclusion that papain cleaves on the amino-terminal side of the disulfide bond, and pepsin cleaves on the carboxyl-terminal side.
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In the "trans" isomer, the two carboxyl groups are always far apart, so hydrogen bonding is not observed.
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The amino terminal might be anchored or in close proximity to the carboxyl terminal for activation of the transducin molecule by rhodopsin.
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Replacement of the succinyl carboxyl group by nitrogen-containing functionalities (amine, amide or guanidine) did not enhance inhibitory activity.
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This allows for stronger hydrogen bonding between the 2- and 3- ribose hydroxyl groups and the side chain carboxyl group.
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It has a hydroxyl group adjacent to the carboxyl group, making it an alpha hydroxy acid (AHA).
en.wikipedia.org
It is active on peptide linkages involving the carboxyl group of lysine or arginine.
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